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Ezigulini ezine-mild dilated cardiomyopathy (MDCM), ukugxila okuphezulu kwe-C-reactive protein (hs-CRP) ebucayi kakhulu kuhlotshaniswa namazinga akhulayo we-N-terminal brain natriuretic peptide (NT-proBNP) ezigulini ezine-mild dilated cardiomyopathy (MDCM) .), nakuba kungekho bufakazi bokusekela umphumela wokubikezela ohambisana nemiphumela yesiguli.Imiphumela yashicilelwa kujenali ye-ESC Heart Failure.
Ukuhlaziywa kwe-retrospective yeziguli ezine-dilated cardiomyopathy (DCM) kanye nengxenye ye-ventricular ejection ye-ventricular engaphansi kuka-50% engeniswe esibhedlela sase-Fuwai e-Beijing, e-China kusukela ngoDisemba 2006 kuya ku-Okthoba 2017.Abaphenyi bafuna ukuqhathanisa ama-biomarker NT-proBNP kanye ne-hs-CRP ezigulini ze-MDCM kanye neziguli ze-DCM.Kulolu cwaningo, i-MDCM yachazwa njengenkomba ye-ventricular end-diastolic diameter index (LVEDDi) ye-33 mm / m2 noma ngaphansi kwabesilisa kanye ne-34 mm / m2 kwabesifazane.
Bangu-640 ababambiqhaza abafakiwe ekuhlaziyweni, kanti i-17% yabo ichazwe njengabane-MDCM kanti ama-83% athathwa njengabane-DCM ekuqaleni.Sekukonke, u-24.8% wabahlanganyeli bekungabesifazane.Iminyaka yobudala yeziguli yayineminyaka engama-49.
Uma kuqhathaniswa nabahlanganyeli be-DCM, iziguli ze-MDCM zazincane, zine-blood pressure ephezulu, isifo sikashukela esiphezulu, izinga eliphansi le-nonsustained ventricular tachycardia, inkomba ephakeme yomzimba, kanye nokuhlala isikhathi esifushane esibhedlela. Ngokuphathelene nama-biomarker enhliziyo, iziguli ezine-MDCM zinezinga eliphansi kakhulu le-NT-proBNP eliphakathi uma kuqhathaniswa neziguli ezine-DCM (2203 pg/mL vs 1448 pg/mL, ngokulandelana; P <.001). Ngokuphathelene nama-biomarker, iziguli ezine-MDCM zinezinga eliphansi kakhulu le-NT-proBNP eliphakathi uma kuqhathaniswa neziguli ezine-DCM yenhliziyo (2203 pg/mL vs 1448 pg/mL, ngokulandelana; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнеентов с пацие 4/20 DC; Ngokuphathelene nama-biomarker enhliziyo, iziguli ze-MDCM zazinamazinga aphansi kakhulu we-NT-proBNP uma kuqhathaniswa neziguli ze-DCM (2203 pg/mL vs. 1448 pg/mL, ngokulandelana; P <0.001).关于心脏生物标志物，与DCM 患者相比，MDCM 患者的NT-proBNP 水平中位数显着降低和（分20别1 pm/Pm4.I-MDCM 患者的NT-proBNP 水平中位数显着降低（分别，与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнечные биомаркеров, 10 пациентов с пациен 1/4 1 DC; Ngokuphathelene nama-biomarker enhliziyo, amazinga e-NT-proBNP asho ukuthi ayephansi kakhulu ezigulini ze-MDCM uma kuqhathaniswa neziguli ze-DCM (2203 pg/mL kanye ne-1448 pg/mL, ngokulandelana; P <0.001).Ngokuphambene, amazinga e-hs-CRP asho ukuthi aphezulu ezigulini ze-MDCM kuneziguli ze-DCM (3.09 mg / L kanye ne-2.79 mg / L, ngokulandelana; P = 0.39).
Phakathi kweziguli ezingama-282 ezathola ukulandelelwa kwe-echocardiographic ngezikhathi zezinyanga eziyisi-6 noma ngaphezulu, iziguli ezingu-7 ezine-MDCM (11.1%) zathuthukisa i-DCM, kuyilapho iziguli ezingu-70 ezine-DCM (32.0%) zabuyela ku-MDCM, njengoba kwenzeka ushintsho ku-LVEDDi.
Iziguli ze-MDCM eziyisisekelo zinengozi ephansi ehlanganisiwe yokufa kwembangela yonke, ukufakelwa kwenhliziyo, nokuphinda kufundwe ukwehluleka kwenhliziyo uma kuqhathaniswa nabahlanganyeli be-DCM (isilinganiso sengozi elungisiwe [aHR], 0.63; 95% CI, 0.43-0.93; P = 0.019).
Womabili amazinga e-hs-CRP ne-NT-proBNP aye ahlotshaniswa ngokuzimela nesiphetho esihlanganisiwe kulo lonke iqembu locwaningo (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 kanye ne-NT-proBNP: aHR , 1.11, 95% CI, 1.02–1.22, p = 0.019).
Ngemva kokuqhathanisa amaphuzu we-propensity phakathi kwe-MDCM ne-DCM, inhlangano phakathi kwamazinga aphezulu e-NT-proBNP kanye nokuphela okuhlanganisiwe kwakuhambisana nalokho okubikiwe ngaphambi kokuqhathanisa iziguli ezine-DCM (RR, 1.83; 95% CI, 1.05-3.20; P = 0.034), kodwa hhayi ezigulini ezine-MDCM (HR, 1.54, 95% CI, 0.76-3.11, P = 0.227).Ngokuphambene nalokho, amazinga e-hs-CRP ayesahlotshaniswa kakhulu nokubikezelwa kweziguli ezine-MDCM (RR 3.19; 95% CI 1.52-6.66; P = 0.002), kodwa hhayi ezigulini ezine-DCM (RR 1.04; 95% CI).0.61–1,79;p = 0.88).
Umkhawulo wocwaningo ukuthi i-phenotype yeziguli ingashintsha ngesikhathi sokulandelwa, nakuba inani labantu abaphinda i-echocardiography lalincane kakhulu, ngakho-ke izibikezelo zokushintsha kwe-phenotypic azizange zihlaziywe.Ukwengeza, ngenxa yobukhulu besampula encane yeziguli ze-MDCM esifundweni, izici eziphazamisayo ezingase zibe khona azizange zilungiswe ngokugcwele ekuhlaziyweni kwe-multivariate.
"Isisekelo se-hs-CRP sasihlotshaniswa nemiphumela ehlangene ezigulini ze-MDCM ngaphambi nangemva kokulungiswa kwama-covariates, kuyilapho i-NT-proBNP ihlotshaniswa kuphela nemiphumela ku-DCM," abalobi bocwaningo bayaphawula."Kudingeka ucwaningo olwengeziwe ukuze kuphenywe izibikezelo zezinguquko zejometri ye-ventricular kanye nomsebenzi wenhliziyo, ikakhulukazi ezigulini ezine-MDCM, ukuze kuhlinzekwe ngengozi enembile kakhulu."
Ukudalula: Akekho noyedwa kubabhali bocwaningo owafuna ukusebenzisana ne-biotech, ekhemisi, kanye/noma nezinkampani zamadivayisi.
Feng J, Tian P, Liang L, et al.Umphumela kanye nevelu yokubikezela ye-N-terminal pro-brain natriuretic peptide kanye ne-high-sensitivity C-reactive protein ku-cardiomyopathies emaphakathi nenwetshiwe.Ukuhluleka kwenhliziyo kwe-ESC.Ishicilelwe ku-inthanethi ngoMashi 4, 2022 doi: 10.1002/ehf2.13864
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