Imikhiqizo

Ukulinganisa okusheshayo kwe-BNP ukuze kutholwe ukuthi isiguli esethula umoya omfishane singase sihlaselwe yisifo senhliziyo esiminyanisa.

I-BNP ifihliwe yi-cardiomyocytes futhi ingavimbela ukwanda kwamangqamuzana e-vascular smooth muscle kanye ne-fibroblasts, edlala indima ebalulekile ekulungisweni kwemithambo yegazi kanye nokulawulwa komfutho wegazi.Esimeni se-hypervolemia noma ezinye izimo ezibangela ukwelula kwe-ventricular, umzimba uhlanganisa i-BNP futhi uyifihle egazini ukuze ulawule ibhalansi yoketshezi lomzimba kanye ne-electrolyte ngokusebenzisana ne-renin angiotensin aldosterone system (RAAS).Ezifweni zenhliziyo nemithambo yegazi ezifana nokuhluleka kwenhliziyo, umfutho wegazi ophakeme, i-acute myocardial infarction, i-myocardial hypertrophy kanye ne-cardiomyopathy, uhlobo lwe-B-ubuchopho be-natriuretic peptide gene expression, synthesis and secretion yanda kakhulu.Ngakho-ke, i-peptide ye-natriuretic yobuchopho ingasetshenziswa ekuxilongeni okuyisizayo kokuhluleka kwenhliziyo.