Izindaba

I-In vitro diagnostics (IVD) idlala indima ebalulekile embonini yezokunakekelwa kwempilo, ivumela ukuxilonga, ukwelashwa, kanye nokuvimbela izifo.Ngokuhamba kweminyaka, isidingo sokuhlolwa kwe-IVD okuphumelelayo, okunembile, futhi okungabizi kakhulu kuye kwaholela ekuthuthukisweni kobuchwepheshe obuhlukahlukene bokuxilonga.Phakathi kwalobu buchwepheshe, i-chemiluminescence ivele njengethuluzi elinamandla, eliguqula insimu ye-IVD.

I-Chemiluminescence: Okuyisisekelo

I-Chemiluminescence yinto eyenzeka lapho ukusabela kwamakhemikhali kukhiqiza ukukhanya.Ku-IVD, ukusabela kuhilela i-enzyme eyenza ukuguqulwa kwe-substrate ibe umkhiqizo okuthi, lapho i-oxidation, ikhiphe ukukhanya.Ama-assays asekelwe ku-Chemiluminescence anohlu olubanzi lwezinhlelo zokusebenza ekuxilongweni, okuhlanganisa i-oncology, izifo ezithathelwanayo, nezifo zenhliziyo.

Ukubaluleka kwe-Chemiluminescence ku-IVD

Ukwethulwa kwe-chemiluminescence ku-IVD kuguqule indlela ukuhlolwa okwenziwa ngayo.Ukuhlolwa kokuxilonga kwangaphambilini kwakudla isikhathi, kudinga amasampula amakhulu, futhi kunokunemba okuphansi.Ukuhlolwa okusekelwe ku-Chemiluminescence kunikeza ukuzwela okuphezulu, ukucaciswa, kanye nobubanzi obuguqukayo obubanzi, okwenza kube nokwenzeka ukuthola ukugxilisa okuphansi kwama-analytes ngevolumu encane yesampula.Imiphumela itholakala ngokushesha nangokunemba okukhulu, okuholela emiphumeleni engcono yomtholampilo.

Ukuhlola Indawo Yokunakekela (POCT) 

Eminyakeni yamuva nje, kube nesidingo esikhulayo se-POCT, ukuhlolwa kokuxilonga kwezokwelapha okwenziwa endaweni yokunakekelwa noma eduze nayo.I-POCT isidume kakhulu ngenxa yokusebenziseka kwayo kalula, imiphumela esheshayo, nezindleko eziphansi.Ukuhlolwa kwe-POCT okusekelwe ku-Chemiluminescence sekuyingxenye yendawo yonke yemboni yezokunakekelwa kwempilo, ukuhlinzeka abahlinzeki bezempilo ngemiphumela cishe esheshayo, okuqeda isidingo sokuthumela amasampula elabhorethri ukuze ahlaziywe.

Amathemba Ekusasa

Imakethe ye-chemiluminescence ku-IVD isakhula, ngesilinganiso sokukhula esihlanganisiwe sonyaka esingaphezu kuka-6% eminyakeni emihlanu ezayo.Lokhu kukhula kungenxa yokwanda kwezifo ezithathelwanayo, ukwanda kwezindleko zokunakekelwa kwezempilo, kanye nesidingo sokuhlolwa kokuxilonga ngokushesha.Ukuvela kobuchwepheshe obusha obuhlanganisa ubuchwepheshe obuhlukahlukene bokuxilonga, njenge-chemiluminescence ne-microfluidics, ithembisa ukuhlolwa okuphumelelayo, ukunciphisa izindleko kanye nesikhathi esidingekayo sokuxilongwa.

Isiphetho

I-Chemiluminescence isiguqule insimu ye-IVD futhi isibe yithuluzi elibalulekile labahlinzeki bezempilo.Ngokunemba kwayo, ukusebenza kahle, kanye nemiphumela esheshayo, iguqule indlela ukuhlola okwenziwa ngayo.Ukusetshenziswa kwayo ku-POCT kwenze iziguli eziningi zithole ukuxilonga kanye nokwelashwa okufika ngesikhathi, kusindisa izimpilo.Ngokuthuthuka kwezobuchwepheshe kanye nezivivinyo ezintsha, ikusasa le-chemiluminescence ku-IVD libukeka liqhakazile.